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<div style="text-align:center; border-width:2px; border-style:solid; border-color:white; border-bottom: 0; padding: 5px 5px 0px 5px;">WARNING TO FEMALES WHO SMOKE </div>

IMPORTANT SAFETY INFORMATION

<div style="text-align: left; margin-left: 5%; margin-right: 5%">*Depending on insurance coverage, eligible patients may pay as little as $0 for each of up to 12 one-month NEXTSTELLIS prescription fills OR each of up to 4 three-month NEXTSTELLIS prescription fills. Check with Pharmacist for copay discount. Maximum savings limits apply; patient out-of-pocket expense will vary. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please see Program Terms, Conditions, and Eligibility Criteria <a target="_blank" href="https://www.nextstellis.com/savings/" style="color:blue">here</a>.</div>

<div style="text-align:left;"> 	What is NEXTSTELLIS? 	NEXTSTELLIS is a prescription combination oral birth control pill used for the prevention of pregnancy. NEXTSTELLIS does not protect against HIV infections (AIDS) and other sexually transmitted diseases. NEXTSTELLIS may be less effective if you have a body mass index (BMI) of 30 or higher. It is not known if NEXTSTELLIS is safe and effective in females with a body mass index (BMI) of 35 or higher. If you are moderately obese, discuss with your healthcare provider whether NEXTSTELLIS is appropriate for you. 	WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT NEXTSTELLIS? <div style="text-align:center; border-width:2px; border-style:solid; border-color:black; padding: 5px 5px 5px 5px; margin-bottom: 10px;"> 	WARNING TO FEMALES WHO SMOKE 	Do not use NEXTSTELLIS if you smoke cigarettes and are over 35 years old. Smoking increases your risk of serious cardiovascular side effects (heart and blood vessel problems) from birth control pills, including death from heart attack, blood clots, or stroke. This risk increases with age and the number of cigarettes you smoke. </div> 	Who should not take NEXTSTELLIS? 	Do not use NEXTSTELLIS if you smoke and are 35 years of age or older. Do not use NEXTSTELLIS if you have or have had blood clots, history of heart attack, stroke or certain heart valve problems, high blood pressure that medicine cannot control, diabetes for more than 20 years, severe migraine headaches with aura, breast cancer or any cancer that is sensitive to female hormones, liver disease or liver tumors, unexplained bleeding from the vagina, have kidney disease or kidney failure, have reduced adrenal gland function, or if you take Hepatitis C drugs containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, as this may increase levels of liver enzymes in the blood. 	What else should I know about taking NEXTSTELLIS? 	Before taking NEXTSTELLIS, tell your healthcare provider about all of your medical conditions, including if you: <ul class="list-d"> 	<li class="fw-b padL25" style="margin-bottom: 5px;">are scheduled for surgery. NEXTSTELLIS may increase your risks of blood clots after surgery. Talk to your healthcare provider about taking NEXTSTELLIS before and after your surgery or if you are going to be unable to walk for an extended period of time.</li> 	<li class="fw-b padL25" style="margin-bottom: 5px;">are depressed now or have been depressed in the past.</li> 	<li class="fw-b padL25" style="margin-bottom: 5px;">had yellowing of your skin or eyes caused by pregnancy.</li> 	<li class="fw-b padL25" style="margin-bottom: 5px;">are pregnant or think you may be pregnant.</li> 	<li class="fw-b padL25" style="margin-bottom: 5px;">are breastfeeding or plan to breastfeed. NEXTSTELLIS may decrease the amount of breast milk you make. NEXTSTELLIS may pass into your breastmilk. Talk to your healthcare provider about the best birth control method for you while breastfeeding.</li> </ul> Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. NEXTSTELLIS may affect the way other medicines work, and other medicines may affect how well NEXTSTELLIS works. What are the most serious risks of taking NEXTSTELLIS? 	NEXTSTELLIS may cause serious side effects that may lead to death including blood clots in your lungs, heart attack, or a stroke. Some other examples of serious blood clots include blood clots in the legs or eyes. Other serious risks include high potassium levels in your blood, high blood pressure, new or worsening headaches including migraine headaches, possible cancer that is sensitive to female hormones, liver problems, changes in the sugar and fat blood levels, gallbladder problems, irregular or unusual vaginal bleeding, spotting, or absence of menstrual periods, depression, possible cancer of the cervix, swelling of the skin especially around the mouth, eyes, and in the throat, and dark patches of skin around your forehead, nose, cheeks, and around your mouth, especially during pregnancy. 	What are the possible side effects of NEXTSTELLIS? 	The most common side effects reported by females taking NEXTSTELLIS in a study were spotting or bleeding between menstrual periods, mood changes, headache, breast tenderness, pain and discomfort, painful periods, acne, weight gain, and decreased sex drive. 	You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a target="_blank" href="http://www.fda.gov/medwatch">http://www.fda.gov/medwatch</a> or call 1-800-FDA-1088. 	Please see the <a style="color:blue" href="https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=c5270073-d083-4109-ae4b-156986175e0a&amp;type=display">full Prescribing Information</a>, including Boxed Warning, and <a style="color:blue" href="https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=c5270073-d083-4109-ae4b-156986175e0a&amp;type=display">Patient Information</a>. </div>

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Say goodbye to modified estrogen. The E4 in NEXTSTELLIS is plant-sourced and is bioidentical to an estrogen that is found naturally in the body during pregnancy.

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What’s stopping you? Covered, eligible patients may pay as little as $0 for each 1-month or 3-month prescription fill* Use your HSA, FSA or Credit Card for your Physician Visit. We believe that you shouldn’t have to settle when it comes to your sexual health. NEXTSTELLIS is the first and only birth control pill with E4.

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